Employing single-molecule optical and AFM imaging and force-spectroscopy approaches, we find to unravel the mechanistic facets of the structure and dynamics of chromosomes. Our exploration passions consist of:
1996, very first mesoscopic cost density waves equipment; and very first electrical measurements on one metallic nanocluster amongst nanoelectrodes
[Laughs] ‘It was definitely a great hazard! At the time, I had been perfectly knowledgeable that it could go Erroneous Which I could grow to be much less successful, but I just disregarded that. Curiosity has normally been my strongest driving pressure. And fortuitously it all labored out.’
2007, first true-time detection of strand Trade in homologous recombination by RecA; discovery of a lower persistence duration of ends of microtubules; and settled the system of biosensing with carbon nanotubes
We acquire position-of-care diagnostics exam of neglected tropical disorders within just resource-limited configurations, determined by Crspr/Cas9 detecting of pathogen’s DNA in physique fluids.
Illustration (3) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is proven in gray, the rim with the pore is highlighted in crimson, and a 3D rendering with the motion of your DNA rod is shown.
Size control of person carbon nanotubes by nanostructuring with the scanning tunneling microscope
Illustration (1) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is revealed in grey, the rim of your pore is highlighted in crimson, in addition to a 3D rendering on the movement in the DNA rod is exhibited.
The rotors harness Vitality from the nanoscale drinking water and ion movement that is created by a static chemical or electrochemical prospective gradient in the nanopore, which happen ceesdekker.net to be proven through a salt gradient or used voltage, respectively. These artificial nanoengines self-Manage and function autonomously in physiological conditions, suggesting solutions to constructing Electrical power-transducing motors at nanoscale interfaces.
Really neat, but that wasn’t truly the place my desire lay. I desired to pioneer and I experienced the sensation that was not attainable, as the most fascinating basic insights experienced now been uncovered. But my field had designed lots of thrilling new equipment to measure particular person molecules. I made a decision which i wanted to use this to biology, to take a look at it from the Bodily point of view.’
An integrated microfluidic platform for quantifying drug permeation across biomimetic vesicle membranes
‘That issues the artificial mobile, as Element of the Dutch BaSyC initiative. Craig Venter seemed best-down in All those times and determined about five hundred genes which have been minimally essential for the performing cell. We wish to glimpse bottom-up: how do we go from the number of molecules to an entire Organic method?
2005, discovery in the system of DNA uncoiling by topoisomerase enzymes; discovery of lengthy-array conformational changes in Mre11/DNA mend complexes; and first power measurements over a DNA molecule in a nanopore
‘I am driven by ponder and issues. On a cloth amount I find answers in physics, but I encounter my deepest joy with God. That faith also drives my science And just how I manage people today.